Carvacrol-rich oregano oil and thymol-rich thyme red oil inhibit biofilm formation and the virulence of uropathogenic Escherichia coli.

Carvacrol-rich oregano oil and thymol-rich thyme red oil inhibit biofilm formation and the virulence of uropathogenic Escherichia coli.

Author Information

Lee JH1, Kim YG1, Lee J1.

1 School of Chemical Engineering, Yeungnam University, Gyeongsan, Korea.

Abstract

AIMS: Urinary tract infections are caused primarily by uropathogenic Escherichia coli (UPEC), and indwelling catheters are usually colonized by UPEC biofilms tolerant to common antibiotics. Hence, UPEC biofilms pose a substantial challenge, and there is an urgent need for effective control strategies.

METHODS AND RESULTS: In this study, 79 essential oils were screened for antibiofilm ability against UPEC. Components of active oils were identified, and their antibiofilm activities were also investigated using 96-well plates with crystal violet assay, scanning electron microscopy, and confocal laser scanning microscopy. Oregano oil and thyme red oil and their major common constituents, carvacrol and thymol, significantly inhibited UPEC biofilm formation at subinhibitory concentrations (<0·01%). These findings were supported by observations that carvacrol and thymol reduced fimbriae production and the swarming motility of UPEC. Furthermore, carvacrol and thymol markedly decreased the hemagglutinating ability of UPEC, and UPEC was more easily killed by human whole blood in the presence of carvacrol and thymol.

CONCLUSIONS: Carvacrol-rich oregano oil and thymol-rich thyme red oil have high antibiofilm and antivirulence activities against UPEC.

SIGNIFICANCE AND IMPACT OF STUDY: In the wake of rising antimicrobial resistance, we envisage that carvacrol and thymol could be used to prevent biofilm formation by UPEC and to reduce its virulence.

You Can Read the Medical Study Here.
All rights reserved by the Authors.

zane hellas

Dear Customer,

Here at Zane Hellas, we take the situation related to minimizing the spread of the coronavirus (COVID-19) and the associated responsibility towards our employees and customers very seriously.

During this challenging period for all humanity where the demand for oregano oil surged, we never thought of taking advantage of the situation and our customers, and we kept our prices constant. Also, we are trying hard to keep all our products available to our loyal customers. However, as the situation becomes more complicated day by day, we noticed that in many cases, we had a significant delay in delivery or even a cancelation.

Under these circumstances, we decided to temporarily shut down our e-shop. Currently, you can find our products available on Amazon. We want to assure you that we are working to find a solution to this problem.

We will notify you when our e-shop is open again.

Until then Stay Home, Stay Healthy